Sterol depletion

Sterol depletion induces epithelial cell dysfunction in flies.

“epithelial cells in the anterior region of the guts of flies fed low sterol diets showed signs of dysfunction prematurely when compared to flies fed adequate sterols.”

Model organismsgutfemales

Dietary sterol depletion is associated with gut dysfunction in Drosophila melanogaster females

bioRxiv (Cold Spring Harbor Laboratory)·Feb 14, 2025Preprint

Sterol depletion shortens lifespan in flies.

“mothers fed low sterol diets both suffer from increased incidence of intestinal permeability and reduced lifespans.”

Model organismsfemales

Dietary sterol depletion is associated with gut dysfunction in Drosophila melanogaster females

bioRxiv (Cold Spring Harbor Laboratory)·Feb 14, 2025Preprint

Sterol depletion increases intestinal permeability in flies.

“mothers fed low sterol diets both suffer from increased incidence of intestinal permeability and reduced lifespans.”

Model organismsgutfemales

Dietary sterol depletion is associated with gut dysfunction in Drosophila melanogaster females

bioRxiv (Cold Spring Harbor Laboratory)·Feb 14, 2025Preprint