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Somatropin + testosterone enanthate

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Human trial1

Outcomes

3

Maximum oxygen uptake

upin humans1

1 study

  1. Somatropin + testosterone enanthate improves maximum oxygen uptake in humans (P<.001).

    “Men's VO(2)max declined by 1.2 mL/min/kg with placebo and by 0.4 mL/min/kg with testosterone (P =.49) but increased with GH (P =.11) and with GH + testosterone (P<.001).”

    Human trial26 weeksmales

    Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial

    JAMA13 Nov 2002

Muscle strength

upin humans1

1 study

  1. Somatropin + testosterone enanthate improves muscle strength in humans (+13.5 kg (P =.05)).

    “Men's strength also did not increase significantly except for a marginally significant increase of 13.5 kg with GH + testosterone (P =.05).”

    Human trial26 weeksmales

    Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial

    JAMA13 Nov 2002

Lean body mass

upin humans1

1 study

  1. Somatropin + testosterone enanthate increases lean body mass in humans (+4.3 kg (P<.001)).

    “In men, LBM increased by 0.1 kg with placebo, 1.4 kg with testosterone (P =.06), 3.1 kg with GH (P<.001), and 4.3 kg with GH + testosterone (P<.001).”

    Human trial26 weeksmales

    Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial

    JAMA13 Nov 2002

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