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Social isolation and loneliness interaction

Social isolation and loneliness interaction has been studied in 1 paper since 2025: 1 observational study in people. The newest paper, May 27, 2025: “Combined association of social isolation and loneliness with frailty onset among independent older adults: A JAGES cohort study”.

Exposure

1 paper studies it1 findingUpdated

“there were no significant multiplicative and additive interaction between social isolation and loneliness on frailty onset”
Combined association of social isolation and loneliness with frailty onset among independent older adults: A JAGES cohort studyArchives of gerontology and geriatrics2025doi:10.1016/j.archger.2025.105914

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Government of Japan Ministry of Health Labour and Welfare and 7 more
  • Humans1

What did studies of Social isolation and loneliness interaction find?

1

Studies of Social isolation and loneliness interaction measured 1 outcome; the most studied are frailty onset (1 study).

Frailty onset

no changein humans1

1 study

  1. Social isolation and loneliness interaction has no effect on frailty onset in humans (multiplicative scale: 0.75 [95 % CI: 0.50-1.11]; RERI:0.29 [95 % CI:1.02-0.44]).

    “there were no significant multiplicative and additive interaction between social isolation and loneliness on frailty onset”

    Humansn = 8,440

    Combined association of social isolation and loneliness with frailty onset among independent older adults: A JAGES cohort study

    Archives of gerontology and geriatrics

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