Social disconnection

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Humans3

Associations

Neighborhood cohesion

downin humans1

1 study

Social disconnection is associated with neighborhood cohesion in humans.
“Less socially connected groups scored lower on extraversion, neighborhood disorder and neighborhood cohesion.”
HumansLess socially connected groupsn = 10,145
Identification and characteristics of social connection latent profiles in older adults: Findings from the Health and Retirement Study
BMC geriatrics7 Oct 2026

Cognitive function

downin humans1

1 study

Social disconnection is associated with cognitive function in humans.
“greater neuroticism, more depressive symptoms, and worse cognitive scores.”
HumansOther social connection profiles compared with the most socially connected profilen = 10,145
Identification and characteristics of social connection latent profiles in older adults: Findings from the Health and Retirement Study
BMC geriatrics7 Oct 2026

Depressive symptoms

upin humans1

1 study

Social disconnection is associated with depressive symptoms in humans.
“greater neuroticism, more depressive symptoms, and worse cognitive scores.”
HumansOther social connection profiles compared with the most socially connected profilen = 10,145
Identification and characteristics of social connection latent profiles in older adults: Findings from the Health and Retirement Study
BMC geriatrics7 Oct 2026