Sigmoidoscopy

4 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: Japan Society for the Promotion of Science

In silico2

Outcomes

Lifetime gained

upin humans1

1 study

Sigmoidoscopy increases lifetime gained in humans (110 days (95% CI, 0-274 days)).
“The only screening test with a significant lifetime gain was sigmoidoscopy (110 days; 95% CI, 0-274 days).”
Human trialcolorectal cancer screening15 years median follow-up
Estimated Lifetime Gained With Cancer Screening Tests: A Meta-Analysis of Randomized Clinical Trials
JAMA internal medicine1 Nov 2023

Colorectal cancer

downin silico1

1 study

Sigmoidoscopy prevents colorectal cancer in silico (cost between $43,000 and $47,000 per year of life gained).
“Screening schedules that include periodic sigmoidoscopy would prevent more cases of cancer but could cost between $43,000 and $47,000 per year of life gained.”
In silico
Cost effectiveness of colorectal cancer screening in the elderly
Annals of internal medicine15 Nov 1991