AgingResearch.NewsJoin free

SHIV-C109P5

Exposure

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute of Diabetes and Digestive and Kidney Diseases and 2 more
  • Animals1

Outcomes

3

Wasting

upin rhesus monkeys1

1 study

  1. SHIV-C109P5 induces wasting in rhesus monkeys (between 3 and 12 weeks post infection).

    “and wasting necessitating euthanasia between 3 and 12 weeks post infection.”

    Animalselderly macaquesbetween 3 and 12 weeks post infectionn = 5

    SHIV-C109p5 NHP induces rapid disease progression in elderly macaques with extensive GI viral replication

    Journal of virology1 Feb 2024

CD4+ T cell count

downin rhesus monkeys1

1 study

  1. SHIV-C109P5 decreases CD4+ T cell count in rhesus monkeys.

    “rapid decrease in CD4+ T cells, CD4+CD8+ T cells, and plasmacytoid dendritic cells”

    Animalselderly macaquesn = 5

    SHIV-C109p5 NHP induces rapid disease progression in elderly macaques with extensive GI viral replication

    Journal of virology1 Feb 2024

More on CD4+ T cell count

Disease progression

upin rhesus monkeys1

1 study

  1. SHIV-C109P5 induces disease progression in rhesus monkeys.

    “Intravenous SHIV-C109p5 infection of aged RMs leads to high plasma viremia and rapid disease progression”

    Animalselderly macaquesn = 5

    SHIV-C109p5 NHP induces rapid disease progression in elderly macaques with extensive GI viral replication

    Journal of virology1 Feb 2024

Latest

Related