Selective breeding

Intervention

2 papers4 findings

  • 2 independent labs in 2 countries
  • 1 finding against
  • Funder: National Institutes of Health
  • Animals2

Outcomes

2

Lifespan

downin M. domesticus1upin M. domesticus1upin mice1

2 studies
  1. Selective breeding decreases lifespan in M. domesticus.

    “Interestingly, the males with the lowest median life expectancy were those in the active selection treatment group.”

    Animalsin active selection treatment groupmales

    The evolution of aging and age-related physical decline in mice selectively bred for high voluntary exercise

    Evolution; international journal of organic evolution1 Jul 2006

  2. Selective breeding increases lifespan in M. domesticus.

    “Median life expectancy was greater for both groups of selection females than for the two complementary groups of control females.”

    Animalsfemales

    The evolution of aging and age-related physical decline in mice selectively bred for high voluntary exercise

    Evolution; international journal of organic evolution1 Jul 2006

  3. Selective breeding extends lifespan in mice (17% longer (377.5 and 436.5 vs 346.8 days)).

    “mean lifespan was 17% longer in the selected lines 121 and 141 (377.5 and 436.5 days, respectively) than the control line 221 (346.8 days)”

    Animalsselective breeding for reproductive longevity

    Lines of mice selected for reproductive longevity

    Growth, development, and aging : GDA1 Jan 1995

Number of parturitions

upin mice1

1 study
  1. Selective breeding increases number of parturitions in mice (80% and 93% greater).

    “Selected lines 121 and 141 had 80% and 93%, respectively, greater number of parturitions during their lifetimes than the control line.”

    Animalslines 121 and 141 vs control line 221

    Lines of mice selected for reproductive longevity

    Growth, development, and aging : GDA1 Jan 1995

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