Selective ablation of P16-LINEAGE hepatocytes

Intervention

1 paper1 finding

  • 1 lab in 1 country
  • Funders: Cancer Research Institute and others
  • Animals1

Outcomes

1

Hepatic steatosis

downin mice1

1 study
  1. Selective ablation of P16-LINEAGE hepatocytes decrease hepatic steatosis in mice (~50% reduction (P < 0.0001)).

    “selective ablation of p16-Lin(+) hepatocytes reduced hepatic lipid accumulation by approximately 50% (P < 0.0001)”

    Animalsin diet-induced MASH modelliver

    Selective ablation of p16Ink4a-lineage hepatocytes attenuates hepatic steatosis in diet-induced MASH

    Biochemical and biophysical research communications5 Aug 2026

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