RO-31-8220
RO-31-8220 has been studied in 1 paper since 2018: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Sep 13, 2018: “Oxidative stress associated with aging activates protein kinase Cε, leading to cilia slowing”.
- 1 lab
- Animals1
What did studies of RO-31-8220 find?
1Studies of RO-31-8220 measured 1 outcome; the most studied are ciliary beat frequency (1 study).
Ciliary beat frequency
upin mice1
1 study
Ciliary beat frequency
upin mice1
RO-31-8220 increases ciliary beat frequency in mice.
“We measured a slowing of CBF with aging that was reversed with inhibition using the novel PKC inhibitor, Ro-31-8220, as well as the PKCε inhibitor, PKCe141.”
Animalsex vivo mouse models of aging
Oxidative stress associated with aging activates protein kinase Cε, leading to cilia slowing
American journal of physiology. Lung cellular and molecular physiology
Latest
American Journal of Physiology Lung Cellular and Molecular Physiology
Oxidative stress associated with aging activates protein kinase Cε, leading to cilia slowing
Experiments in miceOxidative stress and ROS signaling