Rest-activity rhythm fragmentation

Rest-activity rhythm fragmentation has been studied in 2 papers since 2024: 2 observational studies in people; 1 in the past year. The newest story, Nov 6, 2026: “Arthritis linked to more fragmented daily activity rhythms”.

Exposure

2 papers study it3 findingsUpdated Nov 6, 2026

1 new paper in 30 daysSee all 2 papers on rest-activity rhythm fragmentation

At a glance

The findings reach people, from one lab or study. 2 independent labs in 2 countries.

“Each 1-SD higher intradaily variability was associated with all-cause mortality after full adjustment (HR 1.18, 95% CI 1.10-1.26).”

Rest-activity rhythm fragmentation, functional limitation, and mortality in adults with arthritis: A nationally representative cohort studySleep health2026doi:10.1016/j.sleh.2026.10.007

None of its findings points the other way.

2 independent labs in 2 countries

Funders: Alzheimer Nederland and others
2 of 3 findings with company ties

Humans2

What is rest-activity rhythm fragmentation linked with?

Studies link rest-activity rhythm fragmentation with 3 measures: mortality, amyloid-β42/40 ratio and glial fibrillary acidic protein.

Mortality

upin humans1HR 1.18

1 study

Rest-activity rhythm fragmentation is associated with mortality in humans After full adjustment (HR 1.18, 95% CI 1.10-1.26 per 1-SD higher intradaily variability).
“Each 1-SD higher intradaily variability was associated with all-cause mortality after full adjustment (HR 1.18, 95% CI 1.10-1.26).”
HumansAfter full adjustmentEach 1-SD higher intradaily variabilityn = 7,920
Arthritis linked to more fragmented daily activity rhythms
Sleep healthNov 6, 2026

Amyloid-β42/40 ratio

downin humans1

1 study

Rest-activity rhythm fragmentation is associated with amyloid-β42/40 ratio in humans (cognitively unimpaired adults; trend-level association).
“and at trend level with lower Aβ42/40 ratio values (t(85) = -1.95, P = 0.054)”
Humanscognitively unimpaired adults; trend-level associationplasman = 92
Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer's disease pathology
Alzheimer's research & therapyDec 30, 2024

Latest

1 paper in 12 months

Sleep HealthNov 6

Arthritis linked to more fragmented daily activity rhythms

Rhythm fragmentation was 0.063 standard deviations higher in adults with arthritis than in those without it after accounting for demographic and clinical differences.Rhythm fragmentation was 0.063 standard deviations higher in adults with arthritis than in those without it after accounting for demographic and clinical differences.

Cohort · 7,904 peopleArthritis