Rem sleep disturbance
Rem sleep disturbance has been studied in 1 paper since 2025: 1 observational study in people; 1 in the past year. The newest paper, Dec 23, 2025: “REM Sleep is Associated with Cognition and AD Biomarkers Longitudinally in Cognitively Normal and Impaired Older Adults”.
1 paper studies it4 findingsUpdated
“Longitudinally, lower %REM and longer REML were significantly associated with greater decline in PACC5 scores”
None of its findings points the other way.
- 1 lab in 1 country
- Humans1
What is Rem sleep disturbance linked with?
4Studies link Rem sleep disturbance with 4 measures, most often tau PET (1 study), amyloid PET (1) and hippocampal volume (1).
Tau PET
upin humans1
1 study
Tau PET
upin humans1
Rem sleep disturbance predicts tau PET in humans.
“lower %REM and longer REML were significantly associated with greater decline in PACC5 scores, and HCV, as well as increases in amyloid and tau‐PET”
Humanscross-sectionally and longitudinally
AAIC 2025 abstract
Amyloid PET
upin humans1
1 study
Amyloid PET
upin humans1
Rem sleep disturbance predicts amyloid PET in humans.
“lower %REM and longer REML were significantly associated with greater decline in PACC5 scores, and HCV, as well as increases in amyloid and tau‐PET”
Humanscross-sectionally and longitudinally
AAIC 2025 abstract
Hippocampal volume
downin humans1
1 study
Hippocampal volume
downin humans1
Rem sleep disturbance predicts hippocampal volume in humans.
“lower %REM and longer REML were significantly associated with greater decline in PACC5 scores, and HCV”
Humanscross-sectionally and longitudinally
AAIC 2025 abstract
Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
Rem sleep disturbance predicts cognitive function in humans.
“Longitudinally, lower %REM and longer REML were significantly associated with greater decline in PACC5 scores”
Humanscross-sectionally and longitudinally
AAIC 2025 abstract