(r,s)-ketamine

1. (r,s)-ketamine decreases PTGS2 in mice.

   “(R,S)-ketamine reduced Cyclooxygenase 2 expression specifically in ventral Cornu Ammonis region 3 of male mice.”

   Animalscontextual fear-conditioning stressorventral Cornu Ammonis region 3males

   Prophylactic (R,S)-Ketamine Is Effective Against Stress-Induced Behaviors in Adolescent but Not Aged Mice

   The international journal of neuropsychopharmacology·Jun 21, 2022

More on PTGS2

1. (r,s)-ketamine improves contextual fear discrimination in mice.

   “facilitated contextual fear discrimination in both sexes.”

   Animalscontextual fear-conditioning stressor

   Prophylactic (R,S)-Ketamine Is Effective Against Stress-Induced Behaviors in Adolescent but Not Aged Mice

   The international journal of neuropsychopharmacology·Jun 21, 2022

1. (r,s)-ketamine decreases behavioral despair in mice.

   “reduced behavioral despair in males”

   Animalscontextual fear-conditioning stressormales

   Prophylactic (R,S)-Ketamine Is Effective Against Stress-Induced Behaviors in Adolescent but Not Aged Mice

   The international journal of neuropsychopharmacology·Jun 21, 2022

1. (r,s)-ketamine decreases learned fear in mice.

   “(R,S)-ketamine attenuated learned fear and perseverative behavior in females”

   Animalscontextual fear-conditioning stressorfemales

   Prophylactic (R,S)-Ketamine Is Effective Against Stress-Induced Behaviors in Adolescent but Not Aged Mice

   The international journal of neuropsychopharmacology·Jun 21, 2022