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Pyruvate deprivation

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Foundation for Innovative Research Groups of the National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

2

Primordial follicle activation

upin human cells1

1 study

  1. Pyruvate deprivation increases primordial follicle activation in human cells.

    “short-term pyruvate deprivation promoted the activation of human primordial follicles by increasing the glycolysis-related protein levels and mTOR activity in ovarian tissues.”

    Cellsin vitroovary

    Enhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling

    Cell death & disease27 Jan 2022

Glycolysis

upin mouse cells1

1 study

  1. Pyruvate deprivation increases glycolysis in mouse cells.

    “Both short-term pyruvate deprivation in vitro and acute fasting in vivo increased the glycolysis-related gene and protein levels, decreased AMPK activity, and increased mTOR activity in mouse ovaries.”

    Cellsin vitroovary

    Enhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling

    Cell death & disease27 Jan 2022

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