Pufa:sfa ratio

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Institute of Environmental Health Sciences and 4 more

Humans2

Associations

PhenoAge

downin humans2

2 studies

Pufa:sfa ratio is associated with PhenoAge in humans (-1.05 years, 95% CI -1.87 to -0.22).
“a one-unit increase in PUFA:SFA was associated with 1.05 years lower PhenoAge (95% CI = -1.87, -0.22).”
Humansone-unit increase in PUFA:SFAn = 2,260
Dietary fatty acids and epigenetic aging in US adults: results from the National Health and Nutrition Examination Survey
npj aging7 Dec 2025
Pufa:sfa ratio is associated with PhenoAge in humans (1.05 years lower per one-unit increase; 95% CI -1.87 to -0.22).
“Notably, a one-unit increase in PUFA:SFA was associated with 1.05 years lower PhenoAge (95% CI=-1.87, -0.22).”
HumansAdjusted for age, BMI, total energy intake, and sociodemographic and behavioral factorsOne-unit increase in PUFA:SFAn = 2,260
Dietary Fatty Acids and Epigenetic Aging in US Adults: Results from the National Health and Nutrition Examination Survey
medRxiv : the preprint server for health sciences22 Jul 2025Preprint