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Prolactin

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Cells1

Outcomes

4

Cell migration

upin human cells1

1 study

  1. Prolactin increases cell migration in human cells.

    “The results indicate that local PRL triggers EMT, consistent with observed increased migration of HPrEC and PNT2 cells treated with PRL.”

    Cellsprostate

    SUN-096 Local Prostate Prolactin Increases With Age And Promotes DNA Damage And Epithelial-Mesenchymal Transition

    ENDO 2025 abstract22 Oct 2025

CDH1

downin human cells1

1 study

  1. Prolactin decreases CDH1 in human cells.

    “Further, E-cadherin expression was decreased by PRL treatment due to activation of EMT transcription factors including Twist2 and Snail.”

    Cellsprostate

    SUN-096 Local Prostate Prolactin Increases With Age And Promotes DNA Damage And Epithelial-Mesenchymal Transition

    ENDO 2025 abstract22 Oct 2025

More on CDH1

DNA damage

upin human cells1

1 study

  1. Prolactin increases DNA damage in human cells (~70% to ~80% in HPrEC, ~100% in PNT2).

    “DNA damage increased ∼70% to ∼80% in HPrEC lines, and ∼100% in PNT2, after treatment with 100 ng/mL PRL.”

    Cellsprostate100 ng/mL

    SUN-096 Local Prostate Prolactin Increases With Age And Promotes DNA Damage And Epithelial-Mesenchymal Transition

    ENDO 2025 abstract22 Oct 2025

DNA damage response

upin human cells1

1 study

  1. Prolactin induces DNA damage response in human cells.

    “After treating normal human prostate epithelial cells (PNT2) and HPrEC lines with recombinant human PRL for 24 h, we observed dose-dependent increased phosphorylated-H2AX, a marker of DNA damage”

    Cellsprostate24 h

    SUN-096 Local Prostate Prolactin Increases With Age And Promotes DNA Damage And Epithelial-Mesenchymal Transition

    ENDO 2025 abstract22 Oct 2025

More on DNA damage response

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