Principal-component epigenetic clock method

1 paper2 findings

In silico1

Outcomes

2

Detection of clock associations and intervention effects

upin silico1

1 study

Principal-component epigenetic clock method improves detection of clock associations and intervention effects in silico.
“Our retrained principal-component versions of six clocks show agreement between most replicates within 1.5 years, improved detection of clock associations and intervention effects”
In silico
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
Nature aging15 Jul 2022

Epigenetic clock replicate deviation

downin silico1

1 study

Principal-component epigenetic clock method decreases epigenetic clock replicate deviation in silico (within 1.5 years).
“retrained principal-component versions of six clocks show agreement between most replicates within 1.5 years”
In silico
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
Nature aging15 Jul 2022

More on Epigenetic clock replicate deviation

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Nature Aging15 Jul

A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking

Computational studyEpigenetic clock