Polybrominated biphenyls

1. Polybrominated biphenyls induce hepatocellular carcinoma in rats.

   “The incidence of hepatocellular carcinomas was 3/51 (5.9%) and 4/41 (9.6%) after 2 yr in females and males, respectively.”

   Animalstransplacental and lactational exposure200 mg/kg

   Stunted growth, increased mortality, and liver tumors in offspring of polybrominated biphenyl (PBB) dosed sherman rats

   Journal of toxicology and environmental health·1 Jan 1984

More on Hepatocellular carcinoma

1. Polybrominated biphenyls decrease survival in rats (89% vs 98%).

   “Survival rates from birth to weaning were lower in PBB-exposed pups (89%) than in controls (98%).”

   Animalstransplacental and lactational exposure200 mg/kg

   Stunted growth, increased mortality, and liver tumors in offspring of polybrominated biphenyl (PBB) dosed sherman rats

   Journal of toxicology and environmental health·1 Jan 1984

1. Polybrominated biphenyls increase mortality in rats (two times higher (64% vs 32%)).

   “Mortality was two times higher in PBB-exposed males (64%) than in control males (32%) after 2 yr.”

   Animalstransplacental and lactational exposure200 mg/kgmales

   Stunted growth, increased mortality, and liver tumors in offspring of polybrominated biphenyl (PBB) dosed sherman rats

   Journal of toxicology and environmental health·1 Jan 1984

1. Polybrominated biphenyls decrease body weight in rats.

   “Body weights were lower in PBB-exposed rats at ages 1, 6, 12, and 24 mo.”

   Animalstransplacental and lactational exposure200 mg/kg

   Stunted growth, increased mortality, and liver tumors in offspring of polybrominated biphenyl (PBB) dosed sherman rats

   Journal of toxicology and environmental health·1 Jan 1984