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Pladienolide B

Pladienolide B has been studied in 1 paper since 2024: none in people yet, 1 in cells. No study of it in people or animals has been published yet. The newest paper, Aug 8, 2024: “A defective splicing machinery promotes senescence through MDM4 alternative splicing”.

Intervention

1 paper studies it1 findingUpdated

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Canadian Institutes of Health Research and 2 more
  • Cells1

What did studies of Pladienolide B find?

1

Studies of Pladienolide B measured 1 outcome; the most studied are cellular senescence (1 study).

Cellular senescence

upin human cells1

1 study

  1. Pladienolide B induces cellular senescence in human cells.

    “splicing inhibitors herboxidiene, and pladienolide B induced senescence in normal and cancer cell lines”

    Cells

    A defective splicing machinery promotes senescence through MDM4 alternative splicing

    Aging cell

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