Research Square
Compact gene editor enables efficient DNA editing in mice
Viral delivery of the editor in mice reduced a cholesterol-regulating protein by about 82% and LDL cholesterol by about 47%.Viral delivery of the editor in mice reduced a cholesterol-regulating protein by about 82% and LDL cholesterol by about 47%.
Preprint: mouse studyInterventions
Who was studiedMice and mouse zygotes
What changedCirculating PCSK9 fell by about 82% after virus-based delivery of the editor in mice
The catchCirculating PCSK9 reduction is a proxy for DNA-editing efficiency