PGAM1-CHK1 interaction inhibitor
1 paper3 findings
- 1 lab in 1 country
- Funders: Core Research for Evolutional Science and Technology and 4 more
- Animals1
Outcomes
3Physical function
upin mice1
1 study
Physical function
upin mice1
PGAM1-CHK1 interaction inhibitor improves physical function in mice.
“Inhibition of the PGAM1-Chk1 interaction improves physiological parameters during aging and inhibits lung fibrosis in mouse models.”
Animalsduring aging
Signal transduction and targeted therapy15 Dec 2025
Pulmonary fibrosis
downin mice1
1 study
Pulmonary fibrosis
downin mice1
PGAM1-CHK1 interaction inhibitor decreases pulmonary fibrosis in mice.
“Inhibition of the PGAM1-Chk1 interaction improves physiological parameters during aging and inhibits lung fibrosis in mouse models.”
Animalsin mouse models
Signal transduction and targeted therapy15 Dec 2025
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
PGAM1-CHK1 interaction inhibitor decreases cellular senescence in mice.
“Chemical abrogation of PGAM1-Chk1 binding reverts these phenotypes and eliminates SnCs through senolysis.”
Animalschemical abrogation of PGAM1-Chk1 binding
Signal transduction and targeted therapy15 Dec 2025
Latest
1 in 12 monthsSignal Transduction and Targeted Therapy
Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions
Experiments in miceInterventions