PF-04447943
1 paper3 findings
- 1 lab in 1 country
- Funders: American Heart Association and 1 more
- Animals1
Outcomes
3Bradykinin response
no changein mice1
1 study
Bradykinin response
no changein mice1
PF-04447943 has no effect on bradykinin response in mice.
“though it did not affect the bradykinin response.”
Animalsintraperitoneal injectionspulmonary vasculature1 mg/kg/day10 daysmales
GeroScienceJul 9, 2024
Left ventricular diastolic dysfunction
no changein mice1
1 study
Left ventricular diastolic dysfunction
no changein mice1
PF-04447943 has no effect on left ventricular diastolic dysfunction in mice.
“Treatment of aged mice with PF04447943 had no significant effect on LV systolic or diastolic function.”
Animalsintraperitoneal injectionsleft ventricle1 mg/kg/day10 daysmales
GeroScienceJul 9, 2024
Pulmonary vascular resistance
downin mice1
1 study
Pulmonary vascular resistance
downin mice1
PF-04447943 decreases pulmonary vascular resistance in mice.
“PF04447943 treatment normalized PVR and SNP-induced responses”
Animalsintraperitoneal injectionspulmonary vasculature1 mg/kg/day10 daysmales
GeroScienceJul 9, 2024
Latest
GeroScience
Phosphodiesterase 9A inhibition improves aging-related increase in pulmonary vascular resistance in mice
Experiments in miceLung