Percept

Intervention1 paper2 findings

Outcomes

Genome editing

upin mice1Very low certainty

1 study

Percept increases genome editing in mice (56% striatal volume, 78% neurons).
AnimalsTET1-conjugated formulationstriatum
Chemically modified CRISPR enzymes for multi-organ genome editing in vivo · bioRxiv : the preprint server for biology · 16 Sep 2026 · Preprint

Mutant huntingtin aggregate burden

downin mice1Very low certainty

1 study

Percept decreases mutant huntingtin aggregate burden in mice.
Animalsstriatum
Chemically modified CRISPR enzymes for multi-organ genome editing in vivo · bioRxiv : the preprint server for biology · 16 Sep 2026 · Preprint

bioRxivAnimalsPreprint24 Sep