Peptidoglycan

1 paper5 findings

A preprint reports that peptidoglycan extends lifespan in mice and worms, improves mouse healthspan, reduces senescence markers in aged cells and increases lysosomal acidification in cells. All five findings come from one lab in one country, without independent replication; no human studies are reported.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

Lifespan

upin mice1upin worms1

1 study

Peptidoglycan extends lifespan in mice.
Animals
Bacterial Peptidoglycan Extends Lifespan by Activating Lysosomal Activity through V-ATPase Binding
bioRxiv2 Sep 2026Preprint
Peptidoglycan extends lifespan in worms.
Model organisms
Bacterial Peptidoglycan Extends Lifespan by Activating Lysosomal Activity through V-ATPase Binding
bioRxiv2 Sep 2026Preprint

Cellular senescence markers

downin cells1

1 study

Peptidoglycan decreases cellular senescence markers in cells.
Cellsin aged cells
Bacterial Peptidoglycan Extends Lifespan by Activating Lysosomal Activity through V-ATPase Binding
bioRxiv2 Sep 2026Preprint

Latest

1 in 12 months

bioRxiv2 Sep

Bacterial Peptidoglycan Extends Lifespan by Activating Lysosomal Activity through V-ATPase Binding

Preprint: experiments in wormsInterventions

Paper

Peptidoglycan

Outcomes

Latest

Bacterial Peptidoglycan Extends Lifespan by Activating Lysosomal Activity through V-ATPase Binding

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