Pausinystalia macroceras polysaccharides

Intervention

1 paper5 findings

Pausinystalia macroceras polysaccharides extend lifespan in flies and worms; the same model-organism study reports reduced polyglutamine aggregation and activation of FOXO signalling and the NRF2–KEAP1 antioxidant response. All five findings come from one lab, with none pointing the other way; there are no cell, mouse or human results.

  • 1 lab in 1 country
  • Model organisms1

Outcomes

4

Lifespan

upin flies1upin worms1

1 study
  1. Pausinystalia macroceras polysaccharides extend lifespan in flies.

    Model organisms

    Aging-modulatory effects of Pausinystalia macroceras (K. Schum.) Pierre polysaccharides are associated with DAF-16/FOXO and SKN-1/Nrf2 signaling in multiple aging models

    Biogerontology19 Sep 2026

  2. Pausinystalia macroceras polysaccharides extend lifespan in worms.

    Model organisms

    Aging-modulatory effects of Pausinystalia macroceras (K. Schum.) Pierre polysaccharides are associated with DAF-16/FOXO and SKN-1/Nrf2 signaling in multiple aging models

    Biogerontology19 Sep 2026

NRF2–KEAP1 antioxidant response

upin model organisms1

1 study
  1. Pausinystalia macroceras polysaccharides activate NRF2–KEAP1 antioxidant response.

    Model organisms

    Aging-modulatory effects of Pausinystalia macroceras (K. Schum.) Pierre polysaccharides are associated with DAF-16/FOXO and SKN-1/Nrf2 signaling in multiple aging models

    Biogerontology19 Sep 2026

More on NRF2–KEAP1 antioxidant response

FOXO signalling

upin model organisms1

1 study
  1. Pausinystalia macroceras polysaccharides activate FOXO signalling.

    Model organisms

    Aging-modulatory effects of Pausinystalia macroceras (K. Schum.) Pierre polysaccharides are associated with DAF-16/FOXO and SKN-1/Nrf2 signaling in multiple aging models

    Biogerontology19 Sep 2026

More on FOXO signalling

Polyglutamine aggregation

downin model organisms1

1 study
  1. Pausinystalia macroceras polysaccharides decrease polyglutamine aggregation.

    Model organisms

    Aging-modulatory effects of Pausinystalia macroceras (K. Schum.) Pierre polysaccharides are associated with DAF-16/FOXO and SKN-1/Nrf2 signaling in multiple aging models

    Biogerontology19 Sep 2026

More on Polyglutamine aggregation

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