Paraquat

3 findings

PubChem 15939 ChEBI 34905 MeSH D010269

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: Florida Atlantic University and 2 more

Outcomes

3

MitoTimer red:green fluorescence ratio

upin flies1

1 study

Paraquat increases MitoTimer red:green fluorescence ratio in flies.
“Paraquat-supplemented food increased red:green ratios relative to controls, supporting our use of MitoTimer.”
Model organismssupplemented food
Neurons and Glia Exhibit Distinct Age-Associated MitoTimer-Based Mitochondrial Dynamics in the Drosophila Mushroom Body Calyx
microPublication biology18 Aug 2026

More on MitoTimer red:green fluorescence ratio

Behavioral half-life

downin flies1

1 study

Paraquat decreases behavioral half-life in flies (fell 48-53%).
“At 20 mM, T50 fell 48-53% across groups.”
Model organisms20 mM
Differential effects of paraquat-induced oxidative stress on functional aging and lifespan in male and female Drosophila melanogaster
PloS one16 Mar 2026

More on Behavioral half-life

Locomotion

downin flies1

1 study

Paraquat impairs locomotion in flies.
“Paraquat impaired locomotion dose- dependently, with effects modified by genotype and sex”
Model organisms10, or 20 mM
Differential effects of paraquat-induced oxidative stress on functional aging and lifespan in male and female Drosophila melanogaster
PloS one16 Mar 2026

Latest

12 in 12 months

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Mouse Models for Aging Research: Mechanistic Utility, Translational Relevance, and Practical Model Selection

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ALKBH5-Dependent m⁶A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration

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Neurons and Glia Exhibit Distinct Age-Associated MitoTimer-Based Mitochondrial Dynamics in the Drosophila Mushroom Body Calyx

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Research Square27 Aug

Oxidative Stress Resistance of the Extended Longevity Phenotype of Drosophila Under Paraquat Exposure Is Heritable: Influence of Maternal Genotype on the Offspring

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