PAPOE2

1. PAPOE2 increases APOE in mice (57.7 ± 13.8 ng/mg of protein).

   “In vivo brain transfection via nanohybrid/pApoE2 showed significantly higher (p ≤ 0.05) ApoE expression across all treated groups, at 57.7 ± 13.8 ng/mg of protein.”

   Animalsbrain

   Multi-functionalized chitosan-Extracellular vesicles nanohybrid system for intranasal delivery of pApoE2 to attenuate age-related inflammation

   International journal of biological macromolecules·29 May 2026

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1. PAPOE2 decreases IL-1β in mice.

   “The nanohybrid/pApoE2 complex-treated mice have shown a significant reduction in the TNF-α, IL-6, and IL-1β expression in the brain, plasma, and spleen.”

   Animalsin aged micebrain

   Multi-functionalized chitosan-Extracellular vesicles nanohybrid system for intranasal delivery of pApoE2 to attenuate age-related inflammation

   International journal of biological macromolecules·29 May 2026

More on IL-1β

1. PAPOE2 decreases IL-6 in mice.

   “The nanohybrid/pApoE2 complex-treated mice have shown a significant reduction in the TNF-α, IL-6, and IL-1β expression in the brain, plasma, and spleen.”

   Animalsin aged micebrain

   Multi-functionalized chitosan-Extracellular vesicles nanohybrid system for intranasal delivery of pApoE2 to attenuate age-related inflammation

   International journal of biological macromolecules·29 May 2026

More on IL-6

1. PAPOE2 decreases TNF-alpha in mice.

   “The nanohybrid/pApoE2 complex-treated mice have shown a significant reduction in the TNF-α, IL-6, and IL-1β expression in the brain, plasma, and spleen.”

   Animalsin aged micebrain

   Multi-functionalized chitosan-Extracellular vesicles nanohybrid system for intranasal delivery of pApoE2 to attenuate age-related inflammation

   International journal of biological macromolecules·29 May 2026

More on TNF-alpha