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Pair bonding

Pair bonding has been studied in 2 papers since 2020: none in people yet, 2 in animals. The research so far is in animals. The newest paper, Jul 29, 2024: “Epigenetic aging studies of pair bonding in prairie voles”.

Intervention

2 papers study it4 findingsUpdated

See all 2 papers on pair bonding

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

1 of its findings points the other way.

Mice: a single group. Cells, worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: College of Arts and Sciences, Cornell University and 1 more
  • 1 of 4 findings with company ties
  • Animals2

What did studies of pair bonding find?

1

Studies of pair bonding measured one outcome, epigenetic age.

Epigenetic age

no changein M. ochrogaster1downin M. ochrogaster1

2 studies

  1. Pair bonding showed no clear effect on epigenetic age in M. ochrogaster.

    “We did not find evidence that pair-bonded voles exhibit accelerated or decelerated epigenetic aging effects in blood, ear, liver, or brain tissue.”

    Animalsblood, ear, liver, brain

    Epigenetic aging studies of pair bonding in prairie voles

    Scientific reports

  2. Pair bonding decreases epigenetic age in M. ochrogaster (compared with sexually inexperienced voles of the same chronological age) (p = 0.02).

    “sexually inexperienced voles exhibit accelerated epigenetic aging in brain tissue ( p = 0.02) when compared to pair bonded animals of the same chronological age”

    Animalscompared with sexually inexperienced voles of the same chronological agebrain

    Pair bonding slows epigenetic aging and alters methylation in brains of prairie voles

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

More on Epigenetic age

What is pair bonding linked with?

2

Studies link pair bonding with 2 measures: convergent methylation change with aging at four CpGs and CpG methylation at Hnrnph1, Fancl, Fam13b and Fzd1.

Convergent methylation change with aging at four CpGs

mixedin M. ochrogaster1

1 study

  1. Pair bonding is associated with convergent methylation change with aging at four CpGs in M. ochrogaster (CpGs near Bmp4, Eif4g2, Robo1 and Nfat5).

    “four CpGs (near the Bmp4 exon, Eif4g2 3 prime UTR, Robo1 exon, and Nfat5 intron) exhibited a convergent methylation change between pair bonding and aging”

    AnimalsCpGs near Bmp4, Eif4g2, Robo1 and Nfat5

    Pair bonding slows epigenetic aging and alters methylation in brains of prairie voles

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

More on Convergent methylation change with aging at four CpGs

CpG methylation at Hnrnph1, Fancl, Fam13b and Fzd1

mixedin M. ochrogaster1

1 study

  1. Pair bonding is associated with CpG methylation at Hnrnph1, Fancl, Fam13b and Fzd1 in M. ochrogaster (epigenome-wide association across brain, ear and liver).

    “Epigenome wide association studies identified CpGs in four genes that were strongly associated with pair bonding across the three tissue types (brain, ear, and liver)”

    Animalsepigenome-wide association across brain, ear and liver

    Pair bonding slows epigenetic aging and alters methylation in brains of prairie voles

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

More on CpG methylation at Hnrnph1, Fancl, Fam13b and Fzd1

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