P-nad+-np

Intervention

1 paper4 findings

  • 1 lab in 1 country
  • Funder: National Institutes of Health
  • Animals1

Outcomes

4

Re-endothelialization

upin rats1

1 study
  1. P-nad+-np improves re-endothelialization in rats.

    “accelerated the regeneration of EC (re-endothelialization) in vivo”

    Animalspost angioplastysingle-dose

    Targeted NAD + Delivery for Intimal Hyperplasia and Re-endothelialization: A Novel Anti-restenotic Therapy Approach

    bioRxiv (Cold Spring Harbor Laboratory)23 Feb 2024Preprint

Intimal hyperplasia

downin rats1

1 study
  1. P-nad+-np decreases intimal hyperplasia in rats.

    “mitigated IH”

    Animalspost angioplastysingle-dose

    Targeted NAD + Delivery for Intimal Hyperplasia and Re-endothelialization: A Novel Anti-restenotic Therapy Approach

    bioRxiv (Cold Spring Harbor Laboratory)23 Feb 2024Preprint

More on Intimal hyperplasia

Apoptosis

downin human cells1

1 study
  1. P-nad+-np protects against apoptosis in human cells.

    “differentially protecting aortic EC from apoptosis”

    Cellsin human cell primary cultureaorta

    Targeted NAD + Delivery for Intimal Hyperplasia and Re-endothelialization: A Novel Anti-restenotic Therapy Approach

    bioRxiv (Cold Spring Harbor Laboratory)23 Feb 2024Preprint

More on Apoptosis

Smooth muscle cell proliferation

downin human cells1

1 study
  1. P-nad+-np inhibits smooth muscle cell proliferation in human cells.

    “selectively inhibiting the excessive proliferation of aortic SMC”

    Cellsin human cell primary cultureaorta

    Targeted NAD + Delivery for Intimal Hyperplasia and Re-endothelialization: A Novel Anti-restenotic Therapy Approach

    bioRxiv (Cold Spring Harbor Laboratory)23 Feb 2024Preprint

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