ONO-3144
- 1 lab in 1 country
- Animals1
Outcomes
5Blood pressure
no changein rats1
1 study
Blood pressure
no changein rats1
ONO-3144 has no effect on blood pressure in rats.
“ONO-3144 did not affect the growth, blood pressure, concentrations of thyroid hormones and lipids in the blood”
Animalsstroke-prone spontaneously hypertensive ratspowdered chowfrom 2- to 14-month-old
Acta pharmacologica Sinica1 May 2002
Rectal temperature
downin rats1
1 study
Rectal temperature
downin rats1
ONO-3144 decreases rectal temperature in rats.
“decreased the rectal temperature and oxygen consumption rate.”
Animalsstroke-prone spontaneously hypertensive ratspowdered chowfrom 2- to 14-month-old
Acta pharmacologica Sinica1 May 2002
Oxygen consumption rate
downin rats1
1 study
Oxygen consumption rate
downin rats1
ONO-3144 decreases oxygen consumption rate in rats.
“decreased the rectal temperature and oxygen consumption rate.”
Animalsstroke-prone spontaneously hypertensive ratspowdered chowfrom 2- to 14-month-old
Acta pharmacologica Sinica1 May 2002
Sclerosis of retinal artery
downin rats1
1 study
Sclerosis of retinal artery
downin rats1
ONO-3144 prevents sclerosis of retinal artery in rats.
“ONO-3144 also prevented the platelet number decrease, sclerotic change of retinal artery, edematous and hypertrophic changes in parenchymal and circulatory organs.”
Animalsstroke-prone spontaneously hypertensive ratspowdered chowretinal arteryfrom 2- to 14-month-old
Acta pharmacologica Sinica1 May 2002
Lifespan
upin rats1
1 study
Lifespan
upin rats1
ONO-3144 extends lifespan in rats.
“Both the average life-span and the longest life time of SHRSP given 40 mg/kg ONO-3144 were longer than those of normotensive rats and no administration hypertensive rats.”
Animalsstroke-prone spontaneously hypertensive ratspowdered chow40 mg/kgfrom 2- to 14-month-old
Acta pharmacologica Sinica1 May 2002