Nonpharmacological interventions

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Institutes of Health

Outcomes

Depressive symptoms

downin humans1

1 study

Nonpharmacological interventions decrease depressive symptoms in humans (SMD -0.34 to 0.54).
“Nonpharmacological interventions were associated with significant reductions in pain intensity, pain interference, depressive symptoms, catastrophizing beliefs, and improvement in physical performance”
Review
Nonpharmacological Interventions for Chronic Pain in Older Adults: A Systematic Review and Meta-Analysis
The Gerontologist1 Jun 2024

Latest

The Gerontologist1 Jun