Nocturnal intermittent hypoxia
Intervention1 paper5 findings
A human study links nocturnal intermittent hypoxia to increased risks of metabolic syndrome, abdominal obesity, hypertriglyceridaemia and low HDL cholesterol in people initially without metabolic syndrome or abdominal obesity. One result reports an association with metabolic syndrome without specifying direction rather than increased risk; all five findings come from one lab.
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
- Humans1
Associations
4Metabolic syndrome
no changein humans1upin humans1RR 2.1
1 study
Metabolic syndrome
no changein humans1upin humans1RR 2.1
Nocturnal intermittent hypoxia is associated with metabolic syndrome in humans.
Humanswithout baseline MetS and abdominal obesity5.0 yearsn = 647
Effects of nocturnal intermittent hypoxia on metabolic syndrome in Japanese adults without abdominal obesity · International journal of obesity (2005) · 19 Sep 2026
Nocturnal intermittent hypoxia raises the risk of metabolic syndrome in humans (RR 2.10, 95% CI: 1.18-3.76).
Humanswithout baseline MetS and abdominal obesity5.0 yearsn = 647
Effects of nocturnal intermittent hypoxia on metabolic syndrome in Japanese adults without abdominal obesity · International journal of obesity (2005) · 19 Sep 2026
Hypertriglyceridemia
upin humans1RR 2.41
1 study
Hypertriglyceridemia
upin humans1RR 2.41
Nocturnal intermittent hypoxia raises the risk of hypertriglyceridemia in humans (RR 2.41, 95% CI: 1.35-4.30).
Humanswithout baseline MetS and abdominal obesity5.0 yearsn = 647
Effects of nocturnal intermittent hypoxia on metabolic syndrome in Japanese adults without abdominal obesity · International journal of obesity (2005) · 19 Sep 2026
Low high-density lipoprotein cholesterol
upin humans1RR 2.01
1 study
Low high-density lipoprotein cholesterol
upin humans1RR 2.01
Nocturnal intermittent hypoxia raises the risk of low high-density lipoprotein cholesterol in humans (RR 2.01, 95% CI: 1.02-3.96).
Humanswithout baseline MetS and abdominal obesity5.0 yearsn = 647
Effects of nocturnal intermittent hypoxia on metabolic syndrome in Japanese adults without abdominal obesity · International journal of obesity (2005) · 19 Sep 2026
Abdominal obesity
upin humans1RR 2.17
1 study
Abdominal obesity
upin humans1RR 2.17
Nocturnal intermittent hypoxia raises the risk of abdominal obesity in humans (RR 2.17, 95% CI: 1.42-3.33).
Humanswithout baseline MetS and abdominal obesity5.0 yearsn = 647
Effects of nocturnal intermittent hypoxia on metabolic syndrome in Japanese adults without abdominal obesity · International journal of obesity (2005) · 19 Sep 2026