Neuregulin 1
Neuregulin 1 has been studied in 4 papers since 2018: 1 observational study in people, 3 in animals; 1 in the past year. The newest paper, Feb 6, 2026: “Harnessing glucocorticoid receptor antagonism to enhance the efficacy of cardiac regenerative growth factors and cytokines”.
See all 4 papers on neuregulin 1
At a glance
The findings reach mice, none yet in people; independent labs found the same change in cells. 2 independent labs in 2 countries.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: European Commission and 3 more
- Humans1
- Animals3
What did studies of neuregulin 1 find?
1Studies of neuregulin 1 measured 1 outcome; the most studied are cellular senescence (2 studies).
Cellular senescence
downin rat cells2downin mice1
2 studies
Cellular senescence
downin rat cells2downin mice1
Neuregulin 1 decreases cellular senescence in D-galactose-treated GH3 cells.
“treatment with exogenous neuregulin 1 (Nrg1) markedly delayed the senescence of GH3 cells (rat lactotroph cell line) generated by D-galactose (D-gal).”
Cellsin D-galactose-treated GH3 cellspituitary
International journal of biological macromolecules
Neuregulin 1 decreases cellular senescence in mice (streptozotocin-induced diabetes).
“In C57BL/6 male mice rendered diabetic with streptozotocin (STZ), rhNRG-1 attenuated cellular senescence in aortic ECs and SMCs.”
Animalsstreptozotocin-induced diabetesrecombinant humanaortamales
Neuregulin-1 attenuates stress-induced vascular senescence
Cardiovascular research
Neuregulin 1 decreases cellular senescence in rat cells (hydrogen peroxide-induced senescence).
“Recombinant human NRG-1 (rhNRG-1, 20 ng/mL) significantly reduced H2O2-induced senescence, as shown by a lower number of SA-β-gal positive cells”
Cellshydrogen peroxide-induced senescencerecombinant humanaortic endothelial cells and aortic smooth muscle cells20 ng/mL
Neuregulin-1 attenuates stress-induced vascular senescence
Cardiovascular research