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NEP1-40

Intervention

1 paper studies it1 more mentions it2 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: First Affiliated Hospital of Zhengzhou University and 2 more
  • Animals1

Outcomes

2

Synaptic transmission

upin mice1

1 study

  1. NEP1-40 improves synaptic transmission in mice.

    “administering the competitive NgR1 antagonist peptide NEP1-40 (Nogo-A extracellular peptide residues 1-40 amino acids of Nogo-66) and Fasudil (a Rho-kinase inhibitor) effectively mitigated synaptic impairments”

    Animalsfollowing anesthesia and laparotomy surgery

    Hippocampal Nogo66-NgR1 signaling activation restricts postsynaptic assembly in aged mice with postoperative neurocognitive disorders

    Aging cell

Neurocognitive deficits

upin mice1

1 study

  1. NEP1-40 improves neurocognitive deficits in mice.

    “administering the competitive NgR1 antagonist peptide NEP1-40 (Nogo-A extracellular peptide residues 1-40 amino acids of Nogo-66) and Fasudil (a Rho-kinase inhibitor) effectively mitigated synaptic impairments and reversed neurocognitive deficits”

    Animalsfollowing anesthesia and laparotomy surgery

    Hippocampal Nogo66-NgR1 signaling activation restricts postsynaptic assembly in aged mice with postoperative neurocognitive disorders

    Aging cell

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