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Neonatal microglia transplantation

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Lundbeckfonden and 5 more
  • Animals1

Outcomes

4

Cognitive function

upin mice1

1 study

  1. Neonatal microglia transplantation improves cognitive function in mice.

    “and reverses cognitive decline in aged mice.”

    Animalsbrain

    Neonatal Microglia and Their Secretome as Mediators of Brain Repair

    bioRxiv (Cold Spring Harbor Laboratory)22 Sep 2025Preprint

remyelination

upin mice1

1 study

  1. Neonatal microglia transplantation increases remyelination in mice.

    “transplantation of neonatal microglia ameliorates disability, reduces leukocyte infiltration, and promotes remyelination in both inflammatory (EAE) and non-inflammatory (cuprizone) models”

    AnimalsInflammatory EAE and non-inflammatory cuprizone modelscentral nervous system

    Neonatal Microglia and Their Secretome as Mediators of Brain Repair

    bioRxiv (Cold Spring Harbor Laboratory)22 Sep 2025Preprint

Leukocyte infiltration

downin mice1

1 study

  1. Neonatal microglia transplantation decreases leukocyte infiltration in mice.

    “transplantation of neonatal microglia ameliorates disability, reduces leukocyte infiltration”

    AnimalsInflammatory EAE and non-inflammatory cuprizone modelscentral nervous system

    Neonatal Microglia and Their Secretome as Mediators of Brain Repair

    bioRxiv (Cold Spring Harbor Laboratory)22 Sep 2025Preprint

Disability

downin mice1

1 study

  1. Neonatal microglia transplantation decreases disability in mice.

    “transplantation of neonatal microglia ameliorates disability”

    AnimalsInflammatory EAE and non-inflammatory cuprizone modelscentral nervous system

    Neonatal Microglia and Their Secretome as Mediators of Brain Repair

    bioRxiv (Cold Spring Harbor Laboratory)22 Sep 2025Preprint

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