Negative wealth shock

1. Negative wealth shock has no effect on cognitive function in humans (β -0·01 (95% CI -0·24 to 0·22)).

   “but not in England (-0·01; -0·24 to 0·22) or Mexico (-0·11; -0·24 to 0·03).”

   HumansEngland cohortn = 1,184

   Negative wealth shocks in later life and subsequent cognitive function in older adults in China, England, Mexico, and the USA, 2012-18: a population-based, cross-nationally harmonised, longitudinal study

   The lancet. Healthy longevity·Aug 3, 2023

2. Negative wealth shock decreases cognitive function in humans (β -0·16 SD units (95% CI -0·29 to -0·04)).

   “A wealth loss of 75% or greater was negatively associated with subsequent cognitive function in the USA (β -0·16 SD units; 95% CI -0·29 to -0·04)”

   HumansUSA cohortn = 3,292

   Negative wealth shocks in later life and subsequent cognitive function in older adults in China, England, Mexico, and the USA, 2012-18: a population-based, cross-nationally harmonised, longitudinal study

   The lancet. Healthy longevity·Aug 3, 2023

1. Negative wealth shock impairs memory function in humans (-0.08 SD units (95% CI, -0.10 to -0.05)).

   “an acute drop in their level of memory function concurrent with the negative wealth shock (-0.08 SD units; 95% CI, -0.10 to -0.05)”

   Humansconcurrent with shockn = 14,969

   Memory trajectories before and after a negative wealth shock, the United States Health and Retirement Study, 1998-2020

   American journal of epidemiology·Dec 9, 2025

1. Negative wealth shock has no effect on Horvath clock in humans.

   “No significant relationship was found between negative wealth shock and the first-generation epigenetic clocks.”

   Humansn = 3,982

   Negative Wealth Shock and Epigenetic Aging in Middle-Aged and Older Adults

   Gerontology·Sep 18, 2025

More on Horvath clock

1. Negative wealth shock increases Zhang clock in humans.

   “After adjusting for demographic factors and socioeconomic factors, the significant association between negative wealth shock and accelerated aging in DunedinPoAm, Zhang, and GrimAge persisted.”

   Humansadjusted for demographic and socioeconomic factorsn = 3,982

   Negative Wealth Shock and Epigenetic Aging in Middle-Aged and Older Adults

   Gerontology·Sep 18, 2025

More on Zhang clock

1. Negative wealth shock increases DunedinPoAm in humans.

   “After adjusting for demographic factors and socioeconomic factors, the significant association between negative wealth shock and accelerated aging in DunedinPoAm, Zhang, and GrimAge persisted.”

   Humansadjusted for demographic and socioeconomic factorsn = 3,982

   Negative Wealth Shock and Epigenetic Aging in Middle-Aged and Older Adults

   Gerontology·Sep 18, 2025

More on DunedinPoAm

1. Negative wealth shock increases GrimAge in humans.

   “After adjusting for demographic factors and socioeconomic factors, the significant association between negative wealth shock and accelerated aging in DunedinPoAm, Zhang, and GrimAge persisted.”

   Humansadjusted for demographic and socioeconomic factorsn = 3,982

   Negative Wealth Shock and Epigenetic Aging in Middle-Aged and Older Adults

   Gerontology·Sep 18, 2025

More on GrimAge

1. Negative wealth shock is associated with memory decline in humans (-0.04 SD units per decade (95% CI, -0.07 to -0.01)).

   “Participants who experienced a negative wealth shock had faster aging-related memory decline in the years before the shock than their counterparts who did not experience a negative wealth shock”

   Humanspre-shock vs counterparts without shockn = 14,969

   Memory trajectories before and after a negative wealth shock, the United States Health and Retirement Study, 1998-2020

   American journal of epidemiology·Dec 9, 2025