Natural microbiome

Intervention

1 paper2 findings

  • 1 lab in 1 country
  • Funder: Nederlandse Organisatie voor Wetenschappelijk Onderzoek
  • Animals1

Outcomes

2

Naive T cell replacement rate

no changein mice1

1 study
  1. Natural microbiome has no effect on naive T cell replacement rate in mice.

    “naive T cells rarely divide and are replaced by thymic emigrants at similar rates.”

    Animalsin both standard laboratory mice and wildlings

    TRECing down the source: naive and memory T cell generation in dirty mice and men

    Journal of immunology (Baltimore, Md. : 1950)4 Aug 2026

More on Naive T cell replacement rate

Memory T cell replacement rate

upin mice1+50% faster

1 study
  1. Natural microbiome increases memory T cell replacement rate in mice (about 50% faster).

    “The daily replacement rate of memory T cells, on the other hand, is about 50% faster in wildlings than in standard laboratory mice.”

    Animalsin wildlings compared to standard laboratory mice

    TRECing down the source: naive and memory T cell generation in dirty mice and men

    Journal of immunology (Baltimore, Md. : 1950)4 Aug 2026

More on Memory T cell replacement rate

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