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MPTP

Intervention

4 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 3 independent labs in 2 countries
  • Funders: Department of Biotechnology, Ministry of Science and Technology, India and 1 more

What did studies of MPTP find?

3

Studies of MPTP measured 3 outcomes; the most studied are pupillary constriction (1 study), NOS2 (1) and inflammation (1).

Pupillary constriction

downin mice1

1 study

  1. MPTP decreases pupillary constriction in mice.

    “dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) significantly attenuated the gradual pupillary constriction following pupil dilation during dark adaptation in the daytime”

    Animalsin young mice during dark adaptation in the daytime

    Influence of Diurnal Rhythms and Aging on Pupil Size Changes During Dark Adaptation in Mice

    Journal of biological rhythms

NOS2

upin mice1

1 study

  1. MPTP increases NOS2 in mice.

    “MPTP challenge caused upregulation of enzymes MAO-A, MAO-B, and iNOS in both strains.”

    Animalsin ventral midbrain of C57BL/6 J and CD-1 miceventral midbrainmales

    Aging and MPTP Sensitivity Depend on Molecular and Ultrastructural Signatures of Astroglia and Microglia in Mice Substantia Nigra

    Cellular and molecular neurobiology

More on NOS2

Inflammation

upin mice1

1 study

  1. MPTP induces inflammation in mice.

    “MPTP-induced microgliosis and astrogliosis in both strains suggest their involvement in pathogenesis.”

    Animalsin C57BL/6 J and CD-1 micesubstantia nigramales

    Aging and MPTP Sensitivity Depend on Molecular and Ultrastructural Signatures of Astroglia and Microglia in Mice Substantia Nigra

    Cellular and molecular neurobiology

More on Inflammation

What is MPTP linked with?

1

Studies link MPTP with 1 measure, most often Cys106-oxidized DJ-1 (1 study).

Cys106-oxidized DJ-1

mixedin mice1

1 study

  1. MPTP is associated with Cys106-oxidized DJ-1 in mice.

    “MPTP treatment concordantly changed oxDJ-1 levels in PD-related brain sites and heart.”

    AnimalsMPTP-induced Parkinson's disease modelParkinson's disease-related brain sites and heart

    Distribution of oxidized DJ-1 in Parkinson's disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin

    Scientific reports

More on Cys106-oxidized DJ-1