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Mosaic chromosomal alterations

Mosaic chromosomal alterations has been studied in 2 papers since 2023: 2 observational studies in people; 1 in the past year. The newest story, Oct 29, 2026: “Blood-cell chromosome changes linked to disease and death”.

Exposure

2 papers study it5 findingsUpdated

See all 2

“we show that mCAs confer multimorbidity and mortality risk independent of CHIP”
Hematopoietic mosaic chromosomal alterations are pleiotropic drivers of inflammaging, multimorbidity, and mortalitymedRxiv : the preprint server for health sciences2026doi:10.64898/2026.06.24.26356446

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 1 country
  • Funders: National Cancer Institute and 5 more
  • 2 of 5 findings with company ties
  • Humans2

What is Mosaic chromosomal alterations linked with?

5

Studies link Mosaic chromosomal alterations with 5 measures, most often mortality (1 study), multimorbidity (1) and Sex hormone binding globulin polygenic score (1).

Mortality

upin humans1

1 study

  1. Mosaic chromosomal alterations are linked with a higher risk of mortality in humans (independent of CHIP).

    “we show that mCAs confer multimorbidity and mortality risk independent of CHIP”

    Humansindependent of CHIPn = 452,594

    Blood-cell chromosome changes linked to disease and death

    medRxiv : the preprint server for health sciencesPreprint

Multimorbidity

upin humans1

1 study

  1. Mosaic chromosomal alterations are linked with a higher risk of multimorbidity in humans (independent of CHIP).

    “we show that mCAs confer multimorbidity and mortality risk independent of CHIP”

    Humansindependent of CHIPn = 452,594

    Blood-cell chromosome changes linked to disease and death

    medRxiv : the preprint server for health sciencesPreprint

More on Multimorbidity

Sex hormone binding globulin polygenic score

mixedin humans1

1 study

  1. sex hormone binding globulin polygenic score is associated with mosaic chromosomal alterations in humans.

    “Polygenic scores associated with sex hormone binding globulin, vitamin D, and total cholesterol were also associated with mCAs.”

    Humansn = 436,784

    Serum biomarkers are altered in UK Biobank participants with mosaic chromosomal alterations

    Human molecular genetics

Serum biomarkers

mixedin humans1

1 study

  1. Mosaic chromosomal alterations are associated with serum biomarkers in humans (up to 5%).

    “Biomarker levels in participants with mCAs were estimated to differ by up to 5% relative to mCA-free participants”

    Humansn = 436,784

    Serum biomarkers are altered in UK Biobank participants with mosaic chromosomal alterations

    Human molecular genetics

More on Serum biomarkers

Lipids

mixedin humans1

1 study

  1. Mosaic chromosomal alterations are associated with lipids in humans.

    “mCAs were associated with a range of commonly measured serum biomarkers such as lipid levels”

    Humansn = 436,784

    Serum biomarkers are altered in UK Biobank participants with mosaic chromosomal alterations

    Human molecular genetics

More on Lipids

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 1Aug 2026: 0Sep 2026: 0Oct 2026: 01 paper in 12 months
medRxiv

Blood-cell chromosome changes linked to disease and death

Carriers had a higher relative rate of death than noncarriers, with a hazard ratio of 1.21 over a median 14.34 years.Carriers had a higher relative rate of death than noncarriers, with a hazard ratio of 1.21 over a median 14.34 years.

Preprint: cohort · 452,594 peopleMechanisms
Paper

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