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Moringin

Intervention

1 paper2 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Center for Complementary and Integrative Health
  • Model organisms1

Outcomes

2

Lifespan

upin worms1

1 study

  1. Moringin extends lifespan in worms.

    “However, MSE decreased survivability and delayed growth rate, while purified MIC-1 increased the lifespan of C. elegans.”

    Model organisms

    Isothiocyanate-Rich Moringa Seed Extract Activates SKN-1/Nrf2 Pathway in Caenorhabditis elegans

    International journal of molecular sciencesOct 10, 2024

NRF2–KEAP1 antioxidant response

upin worms1

1 study

  1. Moringin activates NRF2–KEAP1 antioxidant response in worms.

    “MSE and MIC-1 upregulate skn-1 expression and induce SKN-1 nuclear translocation, suggesting that they activate the SKN-1/Nrf2 pathway.”

    Model organisms100 μM

    Isothiocyanate-Rich Moringa Seed Extract Activates SKN-1/Nrf2 Pathway in Caenorhabditis elegans

    International journal of molecular sciencesOct 10, 2024

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