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Modified mediterranean-ketogenic diet

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Alzheimer's Disease Research Center, Wake Forest School of Medicine and 2 more
  • Human trial1

Outcomes

4

Cerebral ketone body uptake

upin humans1

1 study

  1. Modified mediterranean-ketogenic diet increases cerebral ketone body uptake in humans.

    “There was increased cerebral perfusion and increased cerebral ketone body uptake (11C-acetoacetate PET, in subsample) following MMKD.”

    Human trialin older adults at risk for Alzheimer'sbrain

    Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study

    Neurobiology of aging26 Sep 2019

Cerebral perfusion

upin humans1

1 study

  1. Modified mediterranean-ketogenic diet increases cerebral perfusion in humans.

    “There was increased cerebral perfusion and increased cerebral ketone body uptake (11C-acetoacetate PET, in subsample) following MMKD.”

    Human trialin older adults at risk for Alzheimer'sbrain

    Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study

    Neurobiology of aging26 Sep 2019

Tau

downin humans1

1 study

  1. Modified mediterranean-ketogenic diet decreases Tau in humans.

    “MMKD was associated with increased cerebrospinal fluid Aβ42 and decreased tau.”

    Human trialin older adults at risk for Alzheimer'scerebrospinal fluidn = 20

    Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study

    Neurobiology of aging26 Sep 2019

More on Tau

Amyloid-beta 42

upin humans1

1 study

  1. Modified mediterranean-ketogenic diet increases amyloid-beta 42 in humans.

    “MMKD was associated with increased cerebrospinal fluid Aβ42 and decreased tau.”

    Human trialin older adults at risk for Alzheimer'scerebrospinal fluidn = 20

    Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study

    Neurobiology of aging26 Sep 2019

More on Amyloid-beta 42

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