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Moderate-to-vigorous intermittent lifestyle physical activity

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: British Heart Foundation and 3 more
  • Humans1

Associations

2

Major adverse cardiovascular events

downin humans1HR 0.71

1 study

  1. Moderate-to-vigorous intermittent lifestyle physical activity lowers the risk of major adverse cardiovascular events in humans (HR 0.71 [0.54-0.93]).

    “risk of MACE was lower for bouts of 1 min to less than 3 min (HR 0·71 [0·54-0·93])”

    Humansin adults who do not exercisemean follow-up 7.9 yearsn = 25,241

    Brief bouts of device-measured intermittent lifestyle physical activity and its association with major adverse cardiovascular events and mortality in people who do not exercise: a prospective cohort study

    The Lancet. Public health1 Oct 2023

More on Major adverse cardiovascular events

Mortality

downin humans1HR 0.66

1 study

  1. Moderate-to-vigorous intermittent lifestyle physical activity lowers the risk of mortality in humans (HR 0.66 [0.53-0.81]).

    “mortality risk was lower for bouts of 1 min to less than 3 min (hazard ratio [HR] 0·66 [0·53-0·81])”

    Humansin adults who do not exercisemean follow-up 7.9 yearsn = 25,241

    Brief bouts of device-measured intermittent lifestyle physical activity and its association with major adverse cardiovascular events and mortality in people who do not exercise: a prospective cohort study

    The Lancet. Public health1 Oct 2023

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