Mito-i
Intervention1 paper4 findings
- Animals1
Outcomes
3Mitophagy
upin human cells1upin mice1Very low certainty
1 study
Mitophagy
upin human cells1upin mice1Very low certainty
Mito-i activates mitophagy in mice.
“Mito-I potently induces mitophagy in human cardiac myocytes derived from induced pluripotent stem cells (hiPSC-CM) and mouse hearts.”
Animalsheart
MITOPHAGY ACTIVATION EXTENDS LONGEVITY AND PREVENTS AGE-RELATED CARDIAC FUNCTIONAL DECLINE · GSA 2024 abstract · 31 Dec 2024
Mito-i activates mitophagy in human cells.
“Mito-I potently induces mitophagy in human cardiac myocytes derived from induced pluripotent stem cells (hiPSC-CM)”
CellshiPSC-CM
MITOPHAGY ACTIVATION EXTENDS LONGEVITY AND PREVENTS AGE-RELATED CARDIAC FUNCTIONAL DECLINE · GSA 2024 abstract · 31 Dec 2024
Cardiovascular function
upin mice1Very low certainty
1 study
Cardiovascular function
upin mice1Very low certainty
Mito-i improves cardiovascular function in mice.
“Mito-I administration in aged (18-month-old) mice alleviates the detrimental effects of aging on cardiovascular health.”
Animalsheart
MITOPHAGY ACTIVATION EXTENDS LONGEVITY AND PREVENTS AGE-RELATED CARDIAC FUNCTIONAL DECLINE · GSA 2024 abstract · 31 Dec 2024
Lifespan
upin worms1Very low certainty
1 study
Lifespan
upin worms1Very low certainty
Mito-i extends lifespan in worms.
“Mito-I treatment extended lifespan in C. elegans.”
Model organisms
MITOPHAGY ACTIVATION EXTENDS LONGEVITY AND PREVENTS AGE-RELATED CARDIAC FUNCTIONAL DECLINE · GSA 2024 abstract · 31 Dec 2024