Minority stress

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 2 countries

Humans1
In silico1

Outcomes

Epigenetic age

upin silico1

1 study

Minority stress increases epigenetic age in silico (6.2 years (95% CI: 5.4–7.0)).
“Minority stress was associated with an average epigenetic age acceleration of 6.2 years (95% CI: 5.4–7.0)”
In silico
AI‐Driven Integration of Minority Stress, Gender‐Affirming Hormone Therapy, and Epigenetic Aging in Alzheimer's Disease Progression in Transgender Individuals
AAIC 2025 abstract23 Dec 2025

Associations

Subjective cognitive decline

upin humans1OR 6.79

1 study

Minority stress raises the risk of subjective cognitive decline in humans (OR = 6.79, p = 0.048).
“worse minority stress was associated with higher risk of SCD for language (OR = 6.79, p = 0.048)”
Humansin sexual minority older adults
Influences of general and specific psycho‐social factors on cognitive health of sexual minority older adults
AAIC 2025 abstract25 Dec 2025