Microglial transplantation

Intervention

1 paper2 findings

  • 1 lab in 1 country
  • Funders: California Institute for Regenerative Medicine and others
  • Animals1

Outcomes

2

Cerebral amyloid angiopathy

downin mice1

1 study
  1. Microglial transplantation protects against cerebral amyloid angiopathy in mice.

    “These results indicate the protective functions of microglia in reducing CAA, blood-brain barrier dysfunction, and brain calcification.”

    Animalsin Alzheimer's disease micebrain

    Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice

    Cell reports14 Jun 2022

More on Cerebral amyloid angiopathy

Premature lethality

downin mice1

1 study
  1. Microglial transplantation protects against premature lethality in mice.

    “A single injection of wild-type microglia into adult mice repopulates the microglial niche and prevents each of these pathological changes.”

    Animalsin Alzheimer's disease micebrain

    Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice

    Cell reports14 Jun 2022

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