Microglial repopulation
1 paper3 findings
- 1 lab in 1 country
- Funders: Japan Society for the Promotion of Science and others
- Animals1
Outcomes
2Attentional set shifting
downin mice1
1 study
Attentional set shifting
downin mice1
Microglial repopulation impairs attentional set shifting in mice.
“microglial repopulation selectively impaired visual discrimination learning and attentional set shifting in aged mice.”
Animalsfollowing PLX3397 withdrawal in C57BL/6J micemales
bioRxiv (Cold Spring Harbor Laboratory)Jan 9, 2026Preprint
Visual discrimination learning
downin mice1
1 study
Visual discrimination learning
downin mice1
Microglial repopulation impairs visual discrimination learning in mice.
“microglial repopulation selectively impaired visual discrimination learning and attentional set shifting in aged mice.”
Animalsfollowing PLX3397 withdrawal in C57BL/6J micemales
bioRxiv (Cold Spring Harbor Laboratory)Jan 9, 2026Preprint
Associations
1Cortical microglial gene expression
mixedin mice1
1 study
Cortical microglial gene expression
mixedin mice1
Microglial repopulation is associated with cortical microglial gene expression in mice.
“Repopulated cortical microglia in aged, but not young, mice exhibited aberrant gene expression patterns”
Animalsfollowing PLX3397 withdrawal in C57BL/6J micecortical microgliamales
bioRxiv (Cold Spring Harbor Laboratory)Jan 9, 2026Preprint
Funding
1 grant since 2025Japan Society for the Promotion of ScienceJP¥4.6m