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M6A inhibition

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 2 more
  • Animals1

Outcomes

2

Temporomandibular joint osteoarthritis

downin rats1

1 study

  1. M6A inhibition decreases temporomandibular joint osteoarthritis in rats.

    “and suppressed TMJOA progression in rats.”

    Animalsin rats

    Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation

    Oral diseasesNov 20, 2023

More on Temporomandibular joint osteoarthritis

Cellular senescence

downin rats1

1 study

  1. M6A inhibition decreases cellular senescence in rats.

    “Moreover, inhibition of m6A modification rescued chondrocyte senescence in vitro and in vivo”

    Animalsin vitro and in vivo

    Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation

    Oral diseasesNov 20, 2023

More on Cellular senescence

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