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Ly-d6/2

Intervention

2 papers study it5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Animals2

Outcomes

4

Physical activity

no changein dogs2

2 studies

  1. Ly-d6/2 has no effect on physical activity in dogs.

    “There were no significant differences between groups in changes in measured activity.”

    Animalsmild to moderate cognitive impairment3 monthsn = 59

    A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination

    Scientific reportsMay 29, 2024

  2. Ly-d6/2 has no effect on physical activity in dogs.

    “There were no significant differences between groups in changes in measured activity.”

    Animals3 months

    A Randomized, Controlled Clinical Trial Demonstrates Improved Cognitive Function in Senior Dogs Supplemented with a Senolytic and NAD+ Precursor Combination

    bioRxiv (Cold Spring Harbor Laboratory)Feb 28, 2024Preprint

Canine Cognitive Dysfunction Rating

downin dogs1

1 study

  1. Ly-d6/2 decreases Canine Cognitive Dysfunction Rating in dogs (p = 0.02).

    “There was a significant difference in CCDR score across treatment groups from baseline to the primary endpoint (p = 0.02) with the largest decrease in the full dose group.”

    Animalsmild to moderate cognitive impairment3 monthsn = 59

    A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination

    Scientific reportsMay 29, 2024

More on Canine Cognitive Dysfunction Rating

Frailty

downin dogs1

1 study

  1. Ly-d6/2 decreases frailty in dogs.

    “the proportion of dogs that improved in frailty and owner-reported activity levels and happiness was higher in the full dose group than other groups”

    Animalsfull dose

    A Randomized, Controlled Clinical Trial Demonstrates Improved Cognitive Function in Senior Dogs Supplemented with a Senolytic and NAD+ Precursor Combination

    bioRxiv (Cold Spring Harbor Laboratory)Feb 28, 2024Preprint

Canine Cognitive Dysfunction Rating scale

downin dogs1

1 study

  1. Ly-d6/2 decreases Canine Cognitive Dysfunction Rating scale in dogs.

    “There was a significant difference in CCDR score across treatment groups from baseline to the primary endpoint (p=0.02) with the largest decrease in the full dose group.”

    Animals3 months

    A Randomized, Controlled Clinical Trial Demonstrates Improved Cognitive Function in Senior Dogs Supplemented with a Senolytic and NAD+ Precursor Combination

    bioRxiv (Cold Spring Harbor Laboratory)Feb 28, 2024Preprint

More on Canine Cognitive Dysfunction Rating scale

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