Life's essential 8

Intervention2 papers4 findings

C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.

1 lab in 1 country1 finding against

Funders: Agencia Estatal de Investigación and 7 more

Humans1

Outcomes

Intrinsic Capacity Impairment Score

no changein humans1downin humans1

1 study

Life's essential 8 has no effect on Intrinsic Capacity Impairment Score in humans (-0.02 points per year (95% CI: -0.16; 0.12)).
Humansper 10-point higher LE85.2-year follow-upn = 2,487
Cardiovascular health, as per life's essential 8, and unhealthy aging trajectories · GeroScience · 23 Sep 2026
Life's essential 8 decreases Intrinsic Capacity Impairment Score in humans (-3.44 points (95% CI: -3.98; -2.91)).
Humansper 10-point higher LE8femalesn = 2,487
Cardiovascular health, as per life's essential 8, and unhealthy aging trajectories · GeroScience · 23 Sep 2026

Intrinsic Capacity Impairment Score →

Deficit Accumulation Index

downin humans1

1 study

Life's essential 8 decreases Deficit Accumulation Index in humans (-2.93 points (95% CI: -3.25; -2.61)).
Humansper 10-point higher LE8femalesn = 2,487
Cardiovascular health, as per life's essential 8, and unhealthy aging trajectories · GeroScience · 23 Sep 2026

Deficit Accumulation Index →