Lentiviral delivery of US2 and SERPINB9
Intervention1 paper2 findings
- Cells1
Outcomes
2PBMC clustering
downin human cells1Very low certainty
1 study
PBMC clustering
downin human cells1Very low certainty
Lentiviral delivery of US2 and SERPINB9 decreases PBMC clustering in human cells.
Cellsaround allogeneic valve cells in vitro
Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune-Shielded Heart Valves · Advanced healthcare materials · 21 Sep 2026
Immune cell-mediated death of donor heart valve cells
downin human cells1Very low certainty
1 study
Immune cell-mediated death of donor heart valve cells
downin human cells1Very low certainty
Lentiviral delivery of US2 and SERPINB9 prevents immune cell-mediated death of donor heart valve cells in human cells.
Cellsby host PBMCs in vitro
Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune-Shielded Heart Valves · Advanced healthcare materials · 21 Sep 2026