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Lacticaseibacillus paracasei + lactiplantibacillus plantarum

Lacticaseibacillus paracasei + lactiplantibacillus plantarum has been studied in 3 papers since 2024: 2 trials in people, 1 in animals; 1 in the past year. The newest story, Nov 9, 2026: “Probiotic did not slow bone loss soon after menopause”.

Intervention

3 papers study it5 findingsUpdated

See all 3 papers on lacticaseibacillus paracasei + lactiplantibacillus plantarum

At a glance

The findings reach people, from one lab or study. 2 independent labs in 3 countries.

“The primary analysis showed a modest but statistically significant greater decline in distal tibia total volumetric BMD in the probiotic group compared with placebo (-3.7 mg HA/cm3; 95% confidence interval: -6.9, -0.4 mg HA/cm3; P = 0.027).”
Effects of 12-month probiotic supplementation on bone mineral density and bone turnover markers in early postmenopausal females: A double-blind randomized controlled trialThe American journal of clinical nutrition2026doi:10.1016/j.ajcnut.2026.101384

1 of its findings points the other way.

Mice and humans: a single group. Cells and worms or flies: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 3 countries
  • 1 finding against
  • Funders: Science for Life Laboratory and 3 more
  • 3 of 5 findings with company ties
  • Human trial2
  • Animals1

Studies in people

1 study gave lacticaseibacillus paracasei + lactiplantibacillus plantarum to people and measured what changed.

What changedDesignPeopleSource

down: Decreases bone mineral density-3.7 mg HA/cm3 (95% CI: -6.9, -0.4)

no change: Has no effect on bone turnover markers

Randomized trial12 mo114 peopleWomen1 to 8 y postmenopausePostmenopausal womenThe American journal of clinical nutrition, Jun 8, 2026

What did studies of lacticaseibacillus paracasei + lactiplantibacillus plantarum find?

4

Studies of lacticaseibacillus paracasei + lactiplantibacillus plantarum measured 4 outcomes, among them bone mineral density, bone turnover markers and bone mineral density.

Bone mineral density

no changein mice1upin mice1

1 study

  1. Lacticaseibacillus paracasei + lactiplantibacillus plantarum showed no clear effect on bone mineral density in mice on high-fat diet.

    “but not in mice on HFD.”

    Animalsin mice on high-fat diet12 weeksfemales

    The beneficial effects of a probiotic mix on bone and lean mass are dependent on the diet in female mice

    Scientific reports

  2. Lacticaseibacillus paracasei + lactiplantibacillus plantarum increases bone mineral density in mice on low-fat diet (p ≤ 0.01).

    “L. Mix treatment increased total body bone mineral density (p ≤ 0.01), by increasing cortical bone area, and total body lean mass (p = 0.035) in mice on LFD”

    Animalsin mice on low-fat diet12 weeksfemales

    The beneficial effects of a probiotic mix on bone and lean mass are dependent on the diet in female mice

    Scientific reports

Bone turnover markers

no changein humans1

1 study

  1. Lacticaseibacillus paracasei + lactiplantibacillus plantarum showed no clear effect on bone turnover markers in humans.

    “No treatment effects were observed for bone turnover, calciotropic, or inflammatory markers.”

    Human trial12 mofemalesn = 114

    Probiotic did not slow bone loss soon after menopause

    The American journal of clinical nutrition

More on Bone turnover markers

Bone mineral density

downin humans1

1 study

  1. Lacticaseibacillus paracasei + lactiplantibacillus plantarum decreases bone mineral density in humans (-3.7 mg HA/cm3 (95% CI: -6.9, -0.4)).

    “The primary analysis showed a modest but statistically significant greater decline in distal tibia total volumetric BMD in the probiotic group compared with placebo (-3.7 mg HA/cm3; 95% confidence interval: -6.9, -0.4 mg HA/cm3; P = 0.027).”

    Human trialtibia12 mofemalesn = 114

    Probiotic did not slow bone loss soon after menopause

    The American journal of clinical nutrition

More on Bone mineral density

Lean mass

upin mice1

1 study

  1. Lacticaseibacillus paracasei + lactiplantibacillus plantarum increases lean mass in mice on low-fat diet (p = 0.035).

    “total body lean mass (p = 0.035) in mice on LFD but not in mice on HFD.”

    Animalsin mice on low-fat diet12 weeksfemales

    The beneficial effects of a probiotic mix on bone and lean mass are dependent on the diet in female mice

    Scientific reports

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 1Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 01 paper in 12 months
The American Journal of Clinical Nutrition

Probiotic did not slow bone loss soon after menopause

Over 12 months, shinbone density near the ankle fell 3.7 milligrams of hydroxyapatite, a bone mineral, per cubic centimeter more with the probiotic than with placebo.Over 12 months, shinbone density near the ankle fell 3.7 milligrams of hydroxyapatite, a bone mineral, per cubic centimeter more with the probiotic than with placebo.

Randomized trial · 114 peopleBones and joints
Paper

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